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1/ A new RCT in @JAMACardio found that vitamin K2, specifically MK7, slowed coronary artery calcification progression compared to placebo in 180 adults over two years.
Promising finding. But it raises a fascinating question about how we measure cardiovascular disease. 🧵
Promising finding. But it raises a fascinating question about how we measure cardiovascular disease. 🧵
2/ And the finding makes sense. Vitamin K2 activates proteins that direct calcium away from arteries and toward bone where it belongs. Sounds like a good thing. But does it help heart and vascular health?
3/ The study randomized 180 adults to either 360 micrograms of MK7 daily or placebo for two years, with CAC and CTAs repeated at baseline, 12 months, and 24 months. Serial measurements, same scanner, two years. That is reasonably rigorous for a supplement trial.
I really liked this.
🧵 thread begins below...
🧵 thread begins below...
I watched it from start to finish for the record.
Truly, I am inspired after listening. Bravo. Well made.
Truly, I am inspired after listening. Bravo. Well made.
The one who refuses to contribute to the group has an unheard opinion that has been devalued from the collective until each member has been given an opportunity to seek clarity with the group.
1/ The Russian government claims that Ukraine's drone attacks against Russia are for political rather than military aims, given the supposed impossibility of a Ukrainian victory. A Russian warblogger warns that this is a dangerous illusion resulting from distorted information. ⬇️
2/ Svyatoslav Golikov, author of the 'Philologist in Ambush' Telegram channel, writes:
3/ "The official domestic information space is circulating the idea that enemy air strikes on critical infrastructure, primarily fuel and energy facilities and logistics,…
Japanese scientists found a death point on your body.
Press it for 30 seconds to reset cortisol and slow cell aging.
They tested 500 volunteers.
Here's the results that even shocked them. 🧵👇
Press it for 30 seconds to reset cortisol and slow cell aging.
They tested 500 volunteers.
Here's the results that even shocked them. 🧵👇
Your cortisol is through the roof.
Constant stress. Faster aging.
Chronic fatigue.
Pills don't help.
Meditation feels useless.
Vacation works for three days... then everything comes back.
Constant stress. Faster aging.
Chronic fatigue.
Pills don't help.
Meditation feels useless.
Vacation works for three days... then everything comes back.
For 20 years, Japanese researchers studied 3 acupuncture points.
They were looking for the one that could instantly lower cortisol.
And they found it.
They were looking for the one that could instantly lower cortisol.
And they found it.
The most dangerous lie in human history isn't about food.
It isn't about medicine. It is about SLEEP.
You don't need 8 hours of sleep. That number was invented in 1938 by a mattress company.
Here's how the biggest lie in history was pulled: (Must Read till end 🪡)
It isn't about medicine. It is about SLEEP.
You don't need 8 hours of sleep. That number was invented in 1938 by a mattress company.
Here's how the biggest lie in history was pulled: (Must Read till end 🪡)
You don't need 8 hours of sleep.
For 200,000 years, humans did not sleep for 8 hours.
That number was invented in 1938 by a mattress company called Simmons Beautyrest.
For 200,000 years, humans did not sleep for 8 hours.
That number was invented in 1938 by a mattress company called Simmons Beautyrest.
Before that campaign, the average human slept in two shifts.
Historians call it "Biphasic Sleep."
You would sleep for 4 hours, wake up for 2, then sleep for another 4.
Historians call it "Biphasic Sleep."
You would sleep for 4 hours, wake up for 2, then sleep for another 4.
In this Ukrainian village, the Old Swedish language has been miraculously preserved.
🧵 1/10 ⬇️
🧵 1/10 ⬇️
Let's explore theological framework called Seven Mountains Dominionism.
GOAL is institutional capture of seven cultural spheres.
Government,
Education,
Media,
Family,
Religion,
Business,
Healthcare.
Not fringe.
Not foreign.
Built HERE over decades.
WOOP WOOP!
Let's roll.
GOAL is institutional capture of seven cultural spheres.
Government,
Education,
Media,
Family,
Religion,
Business,
Healthcare.
Not fringe.
Not foreign.
Built HERE over decades.
WOOP WOOP!
Let's roll.
You are living inside it right now.
In Alberta.
Not metaphorically.
LITERALLY.
Take a gander around you.
It's ok.
You're not alone.
We've got each other, no?
In Alberta.
Not metaphorically.
LITERALLY.
Take a gander around you.
It's ok.
You're not alone.
We've got each other, no?
GOVERNMENT:
Riding associations replaced with ideologically vetted candidates.
Not elected - selected.
The people who choose your choices were chosen first.
Democracy doesn't fail loudly.
It gets quietly replaced.
Silently in the background.
By bad faith actors.
Riding associations replaced with ideologically vetted candidates.
Not elected - selected.
The people who choose your choices were chosen first.
Democracy doesn't fail loudly.
It gets quietly replaced.
Silently in the background.
By bad faith actors.
#ProjectEngine
#BuildInPublic
#FridayFeedback
The end of Sprint 5, Gamification.
🏃 Sprint 6 now for the security aspects
🚜 GitHub utilities to list files and assess security
🧘 Rest, reflect and reset might be a little shorter
🧹 Some cleaning needed before launch
🧵👇
#BuildInPublic
#FridayFeedback
The end of Sprint 5, Gamification.
🏃 Sprint 6 now for the security aspects
🚜 GitHub utilities to list files and assess security
🧘 Rest, reflect and reset might be a little shorter
🧹 Some cleaning needed before launch
🧵👇
🚀 NFT functions for launch?
⬇️ Scope battle continues. Extra function or deliver minimally?
♟️ Public gaming brings in community, which requires security. 🤔
🤯 Launching levels 1-3 seeking audience, which is Level 4. Ironic.
🛡️ A challenge: Discord security is key
🧵👇
⬇️ Scope battle continues. Extra function or deliver minimally?
♟️ Public gaming brings in community, which requires security. 🤔
🤯 Launching levels 1-3 seeking audience, which is Level 4. Ironic.
🛡️ A challenge: Discord security is key
🧵👇
🔎 Immediate focus on which security bots to use in Discord
⛓️ Connecting to NFT providers could add helpful resource
🤖 AI has been fundamental to this build. Listening, checking, critiquing suggesting.
Fatigue is becoming more a factor
🧵✋
⛓️ Connecting to NFT providers could add helpful resource
🤖 AI has been fundamental to this build. Listening, checking, critiquing suggesting.
Fatigue is becoming more a factor
🧵✋
Did you know?
Mother Teresa's Hospice named "Kalighat home for the dying" (Nirmal Hriday) was built upon a famous Hindu temple.
And who granted the land to her for?
A Muslim corporation health officer.
[Thread]
Mother Teresa's Hospice named "Kalighat home for the dying" (Nirmal Hriday) was built upon a famous Hindu temple.
And who granted the land to her for?
A Muslim corporation health officer.
[Thread]
A Hindu property turned into a home for missionary activity, is located right next to the famous Kalighat Temple.
As soon as Teresa learnt that it is a temple of Hindus she took it to turn into her dungeon where she gave the poor people "beautiful death"
As soon as Teresa learnt that it is a temple of Hindus she took it to turn into her dungeon where she gave the poor people "beautiful death"
Hindus ofcrs protested against this encroachment on Hindu property with the co-operation of a Muslim health officer.
But ofcourse nothing happened.
But ofcourse nothing happened.
Lipid Profile vs ApoB & ApoA1: Which Better Predicts Future Heart Disease Risk?
Most people are familiar with cholesterol testing. But increasingly, we are paying attention to two proteins:
🔸Apolipoprotein B (ApoB)
🔸Apolipoprotein A1 (ApoA1)
What are they and should you get them tested?
A thread.
1/n
Most people are familiar with cholesterol testing. But increasingly, we are paying attention to two proteins:
🔸Apolipoprotein B (ApoB)
🔸Apolipoprotein A1 (ApoA1)
What are they and should you get them tested?
A thread.
1/n
Traditionally, cardiovascular risk assessment relies on:
🔸LDL-C ("bad cholesterol")
🔸HDL-C ("good cholesterol")
🔸Triglycerides
🔸Non-HDL cholesterol
These tests remain extremely useful and form the foundation of risk assessment.
2/n
🔸LDL-C ("bad cholesterol")
🔸HDL-C ("good cholesterol")
🔸Triglycerides
🔸Non-HDL cholesterol
These tests remain extremely useful and form the foundation of risk assessment.
2/n
What is ApoB?
🔸ApoB is a protein present on atherogenic ("plaque-forming") particles, which include LDL, VLDL, IDL and Lipoprotein(a).
✅Importantly: One ApoB molecule = One atherogenic particle
3/n
🔸ApoB is a protein present on atherogenic ("plaque-forming") particles, which include LDL, VLDL, IDL and Lipoprotein(a).
✅Importantly: One ApoB molecule = One atherogenic particle
3/n
Reward does not automatically become action.
The brain has to translate it:
past pleasure → future value → effort calculation → planning → goal-directed behaviour
In schizophrenia, this translation process may be impaired.
This is why avolition may be more than just the absence of motivation. 🧵👇
The brain has to translate it:
past pleasure → future value → effort calculation → planning → goal-directed behaviour
In schizophrenia, this translation process may be impaired.
This is why avolition may be more than just the absence of motivation. 🧵👇
In schizophrenia, reward processing is not only about pleasure.
It is about whether reward information can organise behaviour.
So the problem may appear as reduced activity…
But the breakdown may begin before action starts.
It is about whether reward information can organise behaviour.
So the problem may appear as reduced activity…
But the breakdown may begin before action starts.
The key mechanism here points to cortico-striatal dysfunction.
This matters because reward-guided behaviour depends on loops linking frontal regions with the striatum.
These loops help convert reward information into future, effort-requiring action.
This matters because reward-guided behaviour depends on loops linking frontal regions with the striatum.
These loops help convert reward information into future, effort-requiring action.
If I lost all my clients tomorrow, I'd use these 10 ChatGPT prompts to rebuild my freelance business.
1. Find More Clients
Prompt:
"Act as a lead generation expert. Give me 20 potential client types that need [your service]. For each client type, explain their biggest pain points, where they spend time online, and the best outreach strategy to reach them."
Prompt:
"Act as a lead generation expert. Give me 20 potential client types that need [your service]. For each client type, explain their biggest pain points, where they spend time online, and the best outreach strategy to reach them."
2. Write Cold DMs That Get Replies
Prompt:
"Write 5 personalized cold DMs offering [your service] to [target audience]. Make them concise, conversational, value-driven, and focused on starting a conversation rather than making a hard sell."
Prompt:
"Write 5 personalized cold DMs offering [your service] to [target audience]. Make them concise, conversational, value-driven, and focused on starting a conversation rather than making a hard sell."
